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        科學研究 當前位置:首頁 - 重點實驗室 - 科學研究

        國家級項目
        1)題目:線粒體融合蛋白1/2(Mfn1/2)在缺氧肺血管穩態失衡、重構中的作用及分子機制。 課題編號:91339107,金額:100萬元。
        2)題目:15-PGDH/15-KETE在缺氧性肺血管內皮細胞增殖,血管新生中的作用及機制的研究。課題編號:81270113,金額:110萬元。
        3)題目:HO-1在15-LO調控的缺氧肺動脈高壓中的作用及機制研究。課題編號:331071007,金額:33萬元。
        4)題目:缺氧對15-脂氧酶的調控作用及分子機制。課題編號:20112307110022,金額:12萬元。
        5)題目:KATP通道的谷胱甘肽化作為敗血癥嚴重性的標記作用臨床前研究。課題編號:81300192,金額:23萬元。
        6)題目:HL效靈止痛膠囊臨床前研究。課題編號:2009GJB20046,金額:40萬元。
        7)題目:抗體修飾的miR-21脂質體靶向急性缺血心肌的研究 。課題編號:81402865,金額:23萬元。
        8)題目:多肽納米級緩釋膠囊免疫耐受治療實驗性中樞神經。課題編號:30370508。
        9)題目:國家十五科技攻關項目“常用中藥材化學成分及有效成分—垂盆草子的研究”(2000-2003)。
        10)題目:國家“十五”科技攻關引導項目(2004BA754C):骨髓基質干細胞治療神經性自身免疫性疾病的實驗研究(課題參加人)。

        省級項目
        1)題目:抗cTnI抗體修飾隱形脂質體心肌靶向性的研究。 課題編號:D201043,金額:5萬元。
        2)題目:基于多孔殼/膨脹核的聚合物復合微球為載體的脈沖載藥體系的研究。課題編號:QC2001C099,金額:5萬元。
        3)題目:喜樹毛狀要培養體系構建及產物分析。課題編號:C2007-01,金額:3萬元。
        4)題目:蘇木乙酸乙酯提取物中免疫掏活性成分篩選及其作用。課題編號:LRB06-335,金額:2萬元。
        5)題目:東北蒼耳抗癌活性成分研究。課題編號:LC2009C12,金額:5萬元。
        6)題目:RNAi技術結合納米給藥系統治療大鼠心率失常的研究。課題編號:LRB08313,金額:5萬元。
        7)題目:環境因子對喜樹毛狀根生長和喜樹堿合成的影響。 課題編號:11511178
        8)題目:槲寄生自乳化軟膠囊的研究。課題編號:QC2001C099,金額:5萬元。
        9)題目:抗菌肽SMAP-29衍生物的克隆表達及活性研究。課題編號:2006-360。
        10)題目:羧酸酯酶-2作為肝臟惡性腫瘤早期診斷的分子標志物的免疫試劑盒研制。
        11)題目:羧酸酯酶-2在肝臟惡性腫瘤早期診斷中的作用及應用研究。
        12)題目:伏立康唑納米緩釋顆粒的研制及療效分析。
        13)題目:新型腦靶向性脂質體的分布與控制。
        14)題目:無機粒子修飾的阿司匹林及抗胃黏膜損傷研究。
        15)題目:黃芪甲苷分子印跡聚合物微球的制備及黃芪甲苷分離研究。
        16)題目:黃芪甲苷分子印跡聚合物微球的制備及黃芪甲苷分離研究。
        17)題目:基于多孔殼/膨脹核的聚合物復合微球為載體的脈沖載藥體系的研究。
        18)題目:HSYA降低缺氧肺動脈高壓的作用機制研究。
        19)題目:土壤肥力綜合評價與赤芍有效成分芍藥苷含量的研究。省衛生廳。金額:0.5萬。
        20)題目:血經草HPLC指紋圖譜研究。
        21)題目:CIC-3在15-HETE介導的HPV血管重構中的作用及機制。
        22)題目:加味附桂地黃膠囊制劑工藝優化研究。
        23)題目:布地奈德菌群觸發型結腸靶向片的研究。
        24)題目:牛蒡子降血糖活性成分研究 2011省衛生廳。
        25)題目:柿霜PPA粉雙層緩釋口腔貼膜的制備工藝及質量評價研究。
        26)題目:表皮生長因子脂質體透皮貼劑的研究。
        27)題目:黃芪苷抗非甾體抗炎藥導致的胃粘膜損傷的作用及機理研究。
        28)題目:芍藥炮制前后多成分的變化規律。
        29)題目:大慶地區馬齒莧質量標準研究。
        30)題目:中藥薤白抗缺氧性肺動脈高壓的作用及機制研究。
        31)題目:納米生物活性玻璃緩控釋貼劑的研究。
        32)題目:基于代謝組學方法尋找特異性皮炎患者血清中的標志物。
        33)題目:虎杖苷治療肺動脈高壓機制的研究。

        大慶市項目
        1)題目:大慶生物醫藥研發平臺。 課題編號:scx2010-11,金額:200萬元。
        2)題目:中藥現代化研究中心平臺。課題編號:DQGX09NL001,金額:5萬元。
        3)題目:頸松噴霧劑臨床前研究。課題編號:DQGX08YF026,金額:8萬元。
        4)題目:心肌靶向制劑治療心率失常的研究。課題編號:ZHY10-Z101,金額:6萬元。
        5)題目:大慶地產黃芩土壤營養與有效成分相關性的實驗研究。大慶市科學技術計劃項目。金額:3.6萬。
        6)題目:中藥紅花抗肺動脈高壓作用及其機制研究。 
        7)題目:腎復康膠囊的研制。 
        8)題目:具有雙峰釋藥特征的脈沖藥物載體的研究。
        9)題目:板藍根規范化種植種源研究基地合作項目。大慶市大同區。金額:75萬。

        獲得的專利
        ZL200610009931.3    朱大嶺等 
        ZL200610010458.8    朱大嶺等 
        XL200610010342.7    朱大嶺等 
        201210084429.4      魏太明等

        代表性科研成果

        課題名稱 /頒發機構/ 獲獎類型

        肺動脈高壓發病的分子機制及治療藥物的研究/黑龍江省/省政府一等獎      

        肺動脈高壓發病的分子機制及治療藥物的研究/黑龍江省/省政府醫藥衛生科技進步一等獎

        15-LO/15-HETE在缺氧性肺動脈高壓發病中的作用/教育部/自然科學獎二等獎    

        15-HETE致缺氧性肺動脈高壓的分子和離子通道機理/黑龍江省/省政府二等獎     

        細胞色素P450系統在內外源物質代謝中的作用/黑龍江省/省政府二等獎    

        ERK1/2途徑活化于15HETE收縮缺氧大鼠肺動脈的關系/黑龍江省/省政府三等獎    

        缺氧性肺高血壓發病的分子和離子機理/黑龍江省/高??茖W技術一等獎    

        氧化苦參堿對心肌缺血損傷大鼠的心肌保護作用研究/黑龍江省/自然科學技術成果二等獎     

        二氧化鈦接枝的多孔聚苯乙烯-/馬來酸酐納米微球的制備黑龍江省/自然科學技術成果一等獎    

        Voriconazole into PLGA nanoparticles/黑龍江省 /自然科學技術成果二等獎    

        中藥紅花的主要成分HSYA對肺動脈血管的作用/黑龍江省/自然科學技術成果一等獎

        高速逆流法提取分離冬凌草甲素 /黑龍江省/自然科學技術成果二等獎   

        夾竹桃中的強心甾糖苷類生物活性物質研究/黑龍江省/自然科學技術成果三等獎    

        氧化苦參堿抗心律失常作用及機制研究/大慶市 /自然科學技術成果二等獎    

        接枝聚合法制備二氧化鈦/聚苯乙烯-二乙烯苯納米復合微球/大慶市/自然科學技術成果一等獎  
        抗真菌感染藥物納米給藥系統的研究/大慶市/自然科學技術成果二等獎 

         

        SCI文章:

        1. Yu L, Jin X, Cui N, Wu Y, Shi Z, Zhu D, Jiang C. Rosiglitazone selectively inhibits K(ATP) channels by acting on the K(IR) 6 subunit. Br J Pharmacol. 2012. IF=5.881

        2. Guo L, Qiu Z, Wei L, Yu X, Gao X, Jiang S, Tian H, Zhu D. The MicroRNA-328 Regulates Hypoxic Pulmonary Hypertension by Targeting at Insulin Growth Factor 1 Receptor and L-Type Calcium Channel-α1C. Hypertension. 2012. IF=6.908           

        3. Yu L, Liu Y, Qiu Z, Liu S, Gao X, Zhu D. Cellular mechanisms and intracellular signaling pathways for the modulation of eNOS in pulmonary arteries by 15-HETE.

         Recept Signal Transduct Res. 2012.  IF=1.822                                                

        4. Zhu D, Ran Y. Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension. J Physiol Sci. 2012.   IF=1.356                                

        5. Liu Y, Zhang J, Yu L, Cao F, Rao J, Li J, Jiang C, Falck JR, Jacobs ER, Zhu D. A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels. Pulm Pharmacol Ther. 2012. IF= 2.093

        6. Nie X, Song S, Zhang L, Qiu Z, Shi S, Liu Y, Yao L, Zhu D. 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells from apoptosis via inducible nitric oxide synthase (iNOS) pathway. Prostaglandins Other Lipid Mediat. 2012.  IF= 2.033                                                                      

        7. Ma C, Li Y, Ma J, Liu Y, Li Q, Niu S, Shen Z, Zhang L, Pan Z, Zhu D. Key role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension. Hypertension. 2011.    IF=6.908                                                                                                        

        8. Liu Y, Wang R, Li J, Rao J, Li W, Falck JR, Manthati VL, Medhora M, Jacobs ER, Zhu D. Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs.  Hypertens Res. 2011.    IF= 2.353   

        9. Jiang J, Wang S, Wang Z, Ma J, Liu S, Li W, Zhu D. The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells. J Recept Signal Transduct Res. 2011.   IF=1.822                                     

        10. Jingjing Rao, Jing Li, Yun Liu ,Ping Lu, Xiaojiao Sun, P. K. Sugumaran, Daling Zhu. The key role of PGC-1a in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure. Molecular and Cellular Biochemistry. 2012.    IF= 2.168       

        11. Jun Ma, Lei Zhang, Weina Han, Tingting Shen, Cui Ma,  Yun Liu, Xiaowei Nie, Mengmeng Liu, Yajuan Ran, and Daling Zhu. Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells. JLR Papers in Press. 2012.    IF= 6.216      

        12 Yun Liu,Cui,Ma,Qianlong Zhang,Lei Yu,Jun Ma, Lei Zhang, Xuewei Hao, Fang Yuan, Lin Wang, Daling Zhu. the key role of transforming growth factor-beta receptor I and 15- lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cellsThe International Journal of Biochemistry & Cell Biology.2012.     IF= 4.956

        13. Yu L, Jin X, Cui N, Wu Y, Zhu D, Jiang C. Rosiglitazone selectively inhibits KATP channels by acting on the Kir6 subunit. Br J Pharmacol. 2012.  IF= 4.99

        14. Xin Jin, Lei Yu, Shuang Zhang, Yang Wu, Zhenda Shi, Xianfeng Chen, Xiaoli Zhang and Chun Jiang. S-Glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress. J Physiol. 2012.   IF=4.38       

        15. Yu L, Jin XYang YCui NJiang C. Rosiglitazone inhibits vascular K(ATP) channels and coronary vasodilation produced by isoproterenol. Br J Pharmacol. 2011.   IF= 4.99

        16. Yu L, Yun L, Zhaoping Q, Shulin Liu, Xu G, Daling Z. Cellular mechanisms and intracellular signaling pathways for the modulation of eNOS in pulmonary arteries by 15-HETE. Journal of Receptors and Signal Transduction. 2012.   IF=1.611             

        17. Wang Y, Yu L, Cui N, Zhu D, Jiang C. Differential sensitivities of the vascular KATP channel to various PPAR activators. Biochem Pharmacol. 2013.   IF=4.65   

        18. Yang Y, Li S, Konduru AS, Zhang S, Trower TC, Shi W, Cui N, Yu L, Wang Y, Zhu D, Jiang C. Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability. Am J Physiol Cell Physiol. 2012.   IF= 3.674          

        19. Liu Y, Ma C, Zhang Q, Yu L, Ma J, Zhang L, Hao X, Cao F, Wang L, Zhu D. The key role of transforming growth factor-beta receptor I and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells. Int J Biochem Cell Biol. 2012.  IF=4.95                                           

        20. Cui NZhang XTadepalli JSYu LGai HPetit JPamulapati RTJin XJiang C. Involvement of TRP channels in the CO? chemosensitivity of locus coeruleus neurons. J Neurophysiol. 2011.         IF=4.00                       

        21. Liu Y, Zhang J, Yu L, Cao F, Rao J, Li J, Jiang C, Falck JR, Jacobs ER, Zhu D: A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels. Pulm Pharmacol Ther. 2012.     IF=2.09        

        22. Jun Ma, Shujun Liang, Zhigang Wang, Lei Zhang, Jing Jiang, Lei Yu, Xiaodong Zheng, Daling Zhu. ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid mediated the pulmonary vascular remodeling induced by hypoxia in rat. Journal of Cellular Physiology. 2010.    IF =3.87

        23. Ikoba U, Peng HS, Li HC, Miller C, Yu CX, and Wang Q. Nanocarriers in Therapy of Infectious and Inflammatory Diseases. Nanoscale. 2015.      IF=6.739   

        24. Peng HS, Wang C, Yu CX, and Wang Q. An Intestinal Trojan Horse for Gene Delivery. Nanoscale. 2015.          IF=6.739  

        25. Wang Q, Cheng H, Peng HS, Zhou H, Li Peter Y, and Langer R. Non-genetic Engineering of Cells for Drug Delivery and Cell-based Therapy. Advanced drug delivery review. 2015.     IF=12.707                                                                        

        26. Peng HS, Liu XP, Wang R, Jia F, Dong L, and Wang QEmerging Nanostructured Materials for Musculoskeletal Tissue Engineering. J Mater Chem B. 2014. IF=6.636

        27. Sun SL, Guo L, Ren YC, Wang B, Li RH, Qi YS, Yu H, Chang ND, Li MH, and Peng HS. Anti-apoptosis effect of polysaccharide isolated from the seeds of Cuscuta chinensis Lam on cardiomyocytes in aging rats. Mol Biol Rep. 2014.      IF=1.958    

        28. Zhen XE, Zong M, Gao SN, Cao YG, Jiang L, Sun SQ, Peng HS, Bai YH,  Li S. Preparation and Characterization of a novel aspirin derivative with anti-thrombotic and gastric mucosal protection properties. Plos One. 2014.              IF=3.534

        29. Du D, Chang ND, Sun SL, Li MH, Yu H, Liu MF, Liu XY, Wang GT, Li HC, Liu XP, Geng SL, Wang Q, and Peng HS. The Role of Glucose Transporters in Distribution of Liposomes Modified with P-Aminophenyl - α-D-Mannopyranoside in Mice Brain. J Control. Release. 2014.     IF=7.261        

        30. Liu MF, Li MH, Wang GT, Liu XY, Liu DM, Peng HS, and Wang QHeart-targeted nanoscale drug delivery systems. J Biomed. Nanotech. 2014. IF=7.578    

        31. Liu MF, Li MH, Sun SL, Li BX, Du D, Sun JL, Cao FY, Li HC, Jia F, Wang T, Chang ND, Yu H, Wang Q, and Peng HS. The use of antibody modified liposomes loaded with AMO-1 to deliver oligonucleotides to ischemic myocardium for arrhythmia therapy. Biomaterials. 2014.       IF=8.312

        32. Li MH, Yu H, Wang TF, Chang ND, Zhang JQ, Du D, Liu MF, Sun SL, Wang R, Tao HQ, Wang Q, and Peng HS. Tamoxifen Embedded in Lipid Bilayer Improved the Oncotarget of Liposomal Daunorubicin in vivoJ Mater Chem B.     IF=6.636    

        33. Li MH, Deng HB, Peng HS, Wang Q. Functional Nanoparticles in Targeting Glioma Diagnosis and TherapiesJ Nanosci Nanotech. 2014.  IF=1.339  

        34. Niu J, Xing CYan CLiu HCui YPeng H, Chen YLi DJiang CLi NYang H. Lentivirus-mediated CD/TK fusion gene transfection neural stem cell therapy for C6 glioblastoma. Tumor Biol. 2013.     IF=2.840       

        35. Hao ZF, Cui YX, Li MH, Du Dan, Liu MF, Tao HQ, Li S, Cao FY, Chen YL, Lei XH, Wang L, Zhu DL, Peng HS, Jiang CL. Liposomes Modified with P-Aminophenyl-α-D-Mannopyranoside: A Carrier for Targeting Cerebral Functional Regions in Mice. Eur J Pharm Biopharm. 2013.     IF=4.245

        36. Tao HQ, Li MH, Yu H, Liu MF, Du Dan, Sun SL, Yang HC, Wang YM, Ye W, Yang LZ, Zhu DL, Jiang CL, Peng HS. HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia–reperfusion injury in rats. Naunyn-Schmiedeberg's. Arch Pharmacol. 2013.           IF=2.360

        37. Fa He, Yuhua Bai, Jing Wang, Jing Wei, Sen Li, Weili Yang and Chenghua Han. Isolation and Purification of Oridonin from the Whole Plant of Isodon rubescens by High-Speed Counter-Current Chromatography. Molecules. 2011.   IF=2.095   

        38. Ming-Juan Chu, You-ZhiWang, Kiyoshi Itagaki, Hong-Xing Ma, Ping Xin, Xue-Gang Zhou, Guo-You Chen, Sen Li, Shi-Qin Sun. Identification of active compounds from Caesalpinia sappan L. extracts suppressing IL-6 production in RAW 264.7 cells by PLS. Journal of Ethnopharmacology. 2013.       IF=2.939        

        39Zhong-fei Hao, Yu-xia Cui, Ming-hui Li, Dan Du, Mei-fang Liu, Sen Li, Da-ling Zhu, Hai-sheng Peng, Chuan-lu Jiang. Liposomes modified with P-aminophenyl-a-D-mannopyranoside: A carrier for targeting cerebral functional regions in mice. European Journal of Pharmaceutics and Biopharmaceutic.   IF=4.245     

        40、Yuhua Bai, Ping Lu, Chenghua Han, Chunyue Yu, Minggang Chen, Fa He, Lijun Wu. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery. Molecules. 2012.      IF= 2.095

        41、Yuhua Bai, Ming Zhao, Liming Bai, Ryo Hasegawa, Masayoshi Ando. The biological activities of cardenolide triglycosides from stems and twigs, and leaves of Nerium oleander. Journal of Wood Science. 2011.     IF= 0.825

        42、Ming Zhao, Liming Bai, Asami Toki, Ryo Hasegawa, Jun-ichi Sakai, Toshiaki Hasegawa, Tomokazu Mitsui, Yuhua Bai, Mariko Ando, Katsutoshi Hirose and Masayoshi Ando,The Structure of A New Cardenolide Diglycoside and the Biological Activities of Eleven Cardenolide Diglycosides from Nerium oleander. Chemical & Pharmaceutical Bulletin. 2011.   IF = 1.375

        43、Liming BaiMing ZhaoAsami TokiToshiaki HasegawaJun-ichi SakaiXiao-yang YangYuhua Bai, Hirotsugu OguraTomokazu Mitsui and Takao Kataoka, et al. Polar cardenolide monoglycosides from stems and twigs of Nerium oleander and their biological activities. Journal of Wood Science. 2011.  IF= 0.825

        44、Liming Bai, Ming Zhao, Asami Toki, Jun-ichi Sakai, Xiao-yang Yang, Yuhua Bai. Three New Cardenolides from Methanol Extract of Stems and Twigs of Nerium oleander. Chemical & Pharmaceutical Bulletin. 2010.   IF= 1.375                                      

        45、Liyan Wang, Liming Bai, Daiske Tokunaga, Yuusuke Watanabe, Toshiaki Hasegawa, Junichi Sakai, Wanxia Tang, Yuhua Bai, Katsutoshi Hirose, Takao Yamori, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando.The polar neutral and basic taxoids isolated from needles and twigs of taxus cuspidata and their biological activity. Journal of Wood Science. 2008.        IF= 0.825                                                                                                                                                                    

        46、Hasegawa T,Bai J, Dai J, Bai L, Sakai J, Nishizawa S, Bai Yet alSynthesis and Structure-Activity Relationships of Taxuyunnaine C Derivatives as Multidrug Resistance Modulators in MDR Cancer Cells. Bioorganic  Medicinal Chemistry Letters. 2006.         IF=2.331                                

        47、Liyan Wang,Liming Bai,Daisuke Tokunaga,Yuusuke Watanabe,Jun-ichi Sakai,Wanxia Tang,Yuhua Baiet alTwo New Taxoids from the Needles and Young Stems of Taxus cuspidata,Heterocycles. 2008.          IF=0.908   

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