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        劉肖瑩

        發布時間:2022-04-04 13:32:03  作者:本站編輯  來源:本站原創  瀏覽次數:

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        劉肖瑩,女,199011月出生,中共黨員,講師,碩士畢業于哈爾濱醫科大學?,F主持科研課題共5項,參與國家自然基金面上項目、省級重點項目等5項。已發表論文24篇,其中SCI論文16篇,獲黑龍江省省政府自然科學三等獎1項,黑龍江省醫藥衛生科學技術獎一等獎1項,市自然科學成果獎二等獎1項;申報專利8項,授權4項。參加《分子藥劑學》、《群星閃藥》在線課程2項,參編教材3部。主要承擔《藥劑學》、《制劑工程學》、《中藥藥劑學》、《藥劑學實驗》等課程。指導學生獲得國家級大創立項2項,省級大創立項1項。指導學生獲得第六屆互聯網+大賽國家級銅獎、第六屆互聯網+大賽省級金獎、第五屆互聯網+大賽省級金獎、黑龍江省全國移動互聯創新大賽一等獎等10項。

         

        主持和參加科研項目

        1. 哈爾濱醫科大學大慶校區成果轉化培育項目,CXZX-ZXKT03,雙修飾納米顆粒的構建及治療心源性腦卒中的研究,2021.4-2024.4 ,4萬元,在研,主持

        2.伍連德青年科學研究基金,雙修飾納米顆粒的構建及大鼠體內分布的研究,2020/10-2023/10,10萬元,在研,主持

        3.珠海市人民醫院培育項目,新型腦靶向性脂質體治療小鼠腦缺血模型的分布調控及機制研究,2020/02-2023/02,8萬元,在研,主持

        4.哈爾濱醫科大學創新科學研究基金,miR-21納米復合體對急性心肌梗死的治療研究,2018/11-2020/10,4.8萬元,已結題,主持

        5.哈醫大大慶校區校內科研基金,2018XN-22,心肌靶向納米復合體的構建及相關作用機制的研究,2018/08-2021/08,3萬元,已結題,主持

        6.大慶市指導性科技計劃項目, zdy-2016-083,雙靶脂質體體內分布研究,2016/12-2018/04,已結題,主持

        7.國家自然基金面上項目,81671814,糖/抗體/肽靶向納米載體的表面()物質基礎對缺血心肌miR-1/MMP9/Glut1攝取調控機制,2017/01-2018/12,25萬元,已結題,參加

        8.黑龍江省自然基金重點項目,ZD2016013,微環境響應性心靶向納米復合體的構建與療效研究,2016/07-2019/07,20萬元,已結題,參加

        9.黑龍江省普通本科高等學校青年創新人才培養計劃課題,UNPYSCT-2015036,雙靶修飾脂質體治療腦膠質瘤的研究,2016/01-2018/12,10萬元,已結題,參與

         10.企業委托項目,抗感泡騰片的放大工藝研究,2018/9-2019/3,45萬,已結題,參加

         

        發表文章

        1. Bo Yang, Jiaqi Jiang, Lei Jiang, Peiyu Zheng, Fuling Wang, Yang Zhou, Zhong Chen, Minghui Li, Mingming Lian, Shukun Tang, Xiaoying Liu*, Haisheng Peng*, and Qun Wang*. Chitosan mediated solid lipid nanoparticles for enhanced liver delivery of zedoary turmeric oil in vivo. International Journal of Biological Macromolecules. 2020, 149(15): 108-115.

        2. Xiaoying Liu, Shukun Tang, Yuncui Liu, DandanHu, Changmei Zhang, Wenyuan Zhang, Yanqun Chai, Xuefeng Tang, Lei Jiang,Chen Gong, Haisheng Peng*, Minghui Li*. Targeting Regulation of Dually Modified Liposomes by Polyethylene Glycol Length of Vesicle Surface. Journal of Biomedical Nanotechnology. 2019; 12(15): 2413-2427

        3. Haisheng Peng, Xiaoying Liu, Guangtian Wang, Minghui Li, Kaitlin M. Bratlie, Eric Cochran, Qun Wang. Advances of Polymeric Multifunctional Nanomaterials in Theranostics. J. Mater. Chem. B .2015. 3,6856-6870

        4. Wenhua Li, Zhong Chen, Xiaoying Liu, Mingming Lian, Haisheng Peng*, Changmei Zhang*. Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug. Drug Delivery. 2021;28(1):1903-1914.

        5. Wenyuan Zhang, Man Zhao, Yali Gao, Xu Cheng, Xiaoying Liu , Shukun Tang ,Yanbo Peng , Na Wang , Dandan Hu , Haisheng Peng *, Jinqiu Zhang *, Qun Wang*. Biomimetic erythrocytes engineered drug delivery for cancer therapy. Chemical Engineering Journal. 2021

        6. Liwang Shi , Jinqiu Zhang , Man Zhao , Shukun Tang , Xu Cheng , Wenyuan Zhang , Wenhua Li, Xiaoying Liu, Haisheng Peng* , Qun Wang* . Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery. Nanoscale. 2021;13(24):10748-10764.

        7. Minghui Li, Xuefeng Tang, Xiaoying Liu, Xinyu Cui, Mingming Lian, Man Zhao, Haisheng Peng*, Xiaojun Han*. Targeted miR-21 loaded liposomes for acute myocardial infarction. Journal of Materials Chemistry B. 2020

        8. Wenhua Li, Xiaoying Liu, Xu Cheng, Wenyuan Zhang, Chen Gong, Chuya Gao, Haisheng Peng, Bo Yang, Shukun Tang, Haiquan Tao. Effect of Malt-PEG-Abz@RSL3 micelles on HepG2 cells based on NADPH depletion and GPX4 inhibition in ferroptosis. J Drug Target. 2021 Aug 11:1-11. doi: 10.1080/1061186X.2021.1953511. Epub ahead of print. PMID: 34236257.

        9.Changmei Zhang, Zhong Chen, Wenhua LiXiaoying Liu, Shukun Tang, Lei Jiang, Minghui Li, Haisheng Peng *, and Mingming Lian*. Influences of Different Sugar Ligands on Targeted Delivery of Liposomes. Journal of Drug Targeting. 2020; 28(7-8): 789-801

        10. Chunyue Wang, Zhong Chen, Xuefeng Tang, Xiaoying Liu, Na Wang, Wenhua Li*, Ting Liu*. Influences of galactose ligand on the uptake of TADF liposomes by HepG2 cells. Photodiagnosis and Photodynamic Therapy 2020.

        11. Na Wang, Wenyuan Zhang, Dandan Hu, Lei Jiang, Xiaoying Liu, Shukun Tang,

        Xuegang Zhou, Ting Liu, Xuefeng Tang, Yanqun Chai, Minghui Li, Haisheng Peng*,

        Zhimin Du*. ‘Prodrug-like’ acetylmannosamine modified liposomes loaded with arsenic trioxide for the treatment of orthotopic glioma in mice. Journal of Pharmaceutical Sciences. 2020 ;109(9):2861-2873

        12. Lei Jiang, Jiahe Wang, Jiaqi Jiang, Changmei Zhang, Man Zhao, Zhong Chen, Na Wang, Dandan Hu, Xiaoying Liu, Haisheng Peng*, Mingming Lian*. Sonodynamic Therapy in Atherosclerosis by Curcumin Nanosuspensions: Preparation design, Efficacy Evaluation, and Mechanisms Analysis. European Journal of Pharmaceutics and Biopharmaceutics. 2020,146: 101-110.

        13. Meifang Liu, Minghui Li, Guangtian Wang, Xiaoying Liu. Daming Liu, Qun Wang, Haisheng Peng. Heart-Targeted Nanoscale Drug Delivery Systems. Biomedical Nanotechnology. 2014.10, 2038-2062.

        14. Dan Du, Naidan Chang, Souli Sun, Minghui Li, Hui Yu, Meifang Liu, Xiaoying Liu, Guangtian Wang, Haichun Li, Xunpei Liu, Shilong Geng, Qun Wang, Haisheng Peng. The role of glucose transporters in the distribution of p-aminophenyl-α-D- mannopyranoside modified liposomes within mice brain. Journal of controlled release, 2014, 182: 99-110.

        15. Daming Liu, Shukun Tang, Guangtian Wang, Minghui Li, Xiaoying Liu, Haiquan Tao, Yachao Ren, Haisheng Peng, Mingming Lian, and Chuanlu Jiang. The Influences of Dynamic Transport of GLUT1 on the Distribution of Mannosylated Liposomes in Transient Ischemia Reperfusion Mice Brain. J. Biomed. Nanotech. 2017, 13: 638-654.

        16. Jingyan Cao, Ran Wang, Ning Gao, Minghui Li, Xuyu Tian, Weili Yang, Ying Ruan, Chunlan Zhou, Guangtian Wang, Xiaoying Liu, Shukun Tang, Yan Yu, Ying Liu, Guangyu Sun, Haisheng Peng*, and Qun Wang*. A7RC peptide modified paclitaxel liposomes dually target breast cancer. Biomaterials Science. 2015, 3: 1545- 1554.

         

         獲獎情況

        1. 黑龍江省省政府自然科學三等獎,心腦及腫瘤缺血組織靶向制劑設計及機理研究,2019

        2. 黑龍江省醫藥衛生科學技術一等獎,心腦及腫瘤缺血組織靶向制劑設計及機理研究,2019

        3. 用于治療疾病的多功能納米聚合物的研究,大慶市科技局,大慶市第二十六屆自然科學技術學術成果獎,二等獎,2017

         

        專利

        1.一種心腦雙靶向脂質體及其制備方法和應用。批準號:ZL201810299429.3

        2.一種抗心肌肌鈣蛋白抗體修飾并載有miR-21的脂質體及其制備方法和應用。批準號:ZL20181098620.X

        3.一種乙?;酋?/span>-聚乙二醇-磷脂酰乙醇胺共軛物及其制備方法與應用。批準號: ZL201810301839.7

        4.-聚乙二醇-DSPE偶聯化合物及其制備方法與應用。批準號:ZL 201811062535.6

        5.一系列熱激活延遲熒光(TADF)納米探針制備及其在生物成像中的應用。申請號:201811325113.3

        6.聚乙二醇修飾的人胸腺素β4二串體蛋白及其制備方法和應用。申請號:201911001508.2

        7.一種鄰細胞間相互作用的研究方法。申請號:201910886668.3

        8.一種糖基聯合細胞穿透肽修飾的腦靶向納米脂質體及其制備方法與應用。申請號:202010121215.4

         

        主持和參加教學項目

        1. 哈爾濱醫科大學校內教研課題,專創融合視域下中藥學專業人才培養模式的研究,2021.3-2023.12,在研,主持人

        2. 哈爾濱醫科大學思想政治教育工作科研基金立項課題資助特殊學情思政教育干預研究, 2018.03-2019.03,結題,參與

        3. 國家級大創立項,合成磷脂,2020/1-2021/1,1萬元,在研,指導教師

        4. 國家級大創立項,元氣滿滿即食人參,2021/1-2022/1,1萬元,在研,第一指導教師

        5. 省級大創立項,藍莓山藥咀嚼片,2020/1-2021/1,0.5萬元,在研,指導教師


         

        教育經歷

        2013/09-2016/06,哈爾濱醫科大學,大慶校區藥學院,碩士,導師:彭海生

        2009/09-2013/06,哈爾濱醫科大學,大慶校區藥學院,學士

         

        研究工作經歷

        2016.7 - 至今,哈醫大大慶校區 藥學院 藥劑教研室 助教

        2018.10 - 至今,哈醫大大慶校區 藥學院 藥劑教研室 秘書

         


        地址:黑龍江省大慶市高新區新陽路 39 郵政編碼:163319
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        版權所有:哈爾濱醫科大學大慶校區
        地址:黑龍江省大慶市高新區新陽路39
        黑ICP備2021002235號-1
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